Cameroon failed to get the point they needed to qualify for the 2002 World Cup finals and lost 2-0 in Angola.
Cameroon still lead the group A section by four points and play again at the start of July to try and seal their place in Japan and South Korea.
They host Togo who beat Zambia 3-2 at the weekend.
A 59th minute goal from Akwa - Angola's all-time top scorer - at close range and ten minutes later Quinzinho sealed the win with a well-timed cross shot.
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